Active Ingredients:

An opaque fluid vaccine prepared from the purified formol toxoids of Clostridium perfringens (C. welchii) type D, Clostridium septicum, Clostridium tetani, purified formalin-killed cultures of Clostridium chauvoei, and antigens from the epidemiologically most important A and T serotypes of Mannheimia (Pasteurella) haemolytica in buffered physiological saline and adsorbed onto aluminum hydroxide. Preservative: Thiomersal 0.013%.

Indications:

For the active immunization of sheep against pulpy kidney, malignant edema, blackquarter, tetanus, and pasteurellosis caused by the organisms listed below. In particular, the vaccine is recommended as an aid in the prevention of pneumonic and septicaemic pasteurellosis in lambs.

Dosage and Administration:

• Sheep of all ages should be given 2 mL subcutaneous injection with the dosage repeated after an interval of 4 to 6 weeks.
• Lambs born to vaccinated ewes could be expected to have colostrum protection for up to 4 weeks against Mannheimia (Pasteurella) haemolytica and for up to 12 weeks against the clostridial diseases listed above.
• Lambs being retained will thus require a full vaccination program themselves. The timing of the first injection should be carefully considered so that the full vaccination program can be completed before the period of expected risk of diseases due to Mannheimia (Pasteurella) haemolytica or clostridia.
• Pasteurellosis due to infection with Mannheimia (Pasteurella) haemolytica A serotypes usually occurs in late spring or early summer, whereas septicaemic pasteurellosis associated with infection due to Mannheimia (Pasteurella) haemolytica T serotypes usually occurs in late summer or autumn.
• Lambs born to unvaccinated ewes should be given a first injection of 2 mL vaccine during the first week of life and a second 2 mL injection 4 to 6 weeks later.
• In areas of high incidence of pulpy kidney disease, it may be advisable to give a third dose of vaccine to lambs born early in the year during the first year of life.

Withdrawal Period:

No specific information provided.

Warnings:

• The vaccine contains an adjuvant which may cause a temporary nodule at the site of injection.
• In any group of animals, a small number of individuals may fail to respond to vaccination as a result of immunological incompetence or for some other reason.
• Significant levels of immunity cannot be expected until two weeks after the second dose of the primary vaccination course.
• Stress should be avoided when vaccinating animals, particularly during later stages of pregnancy.
• Occasional hypersensitivity reactions may occur.
• Dispose of any unused vaccine and empty vaccine containers according to local waste disposal regulations.
• KEEP OUT OF REACH FROM CHILDREN, UNINFORMED PERSONS, AND ANIMALS.
• If the remedy's effectiveness is suspected, seek veterinary advice and notify the registration holder.

Target Species:

Sheep

Packaging Sizes:

100 mL (50 doses) and 500 mL (250 doses) collapsible low-density polyethylene containers.

Storage Requirements:

• Store in a cool place between 2 °C and 8 °C. If stored in a refrigerator at between 2 °C and 8 °C, it may be expected to retain its potency up to the expiry date printed on the package.
• Do not freeze.
• Protect from light.

Manufacturer Information:

Registration Holder: Intervet South Africa (Pty) Ltd.
20 Spartan Road, Spartan, 1619, RSA
Tel: +27 (0) 11 923 9300
Fax: +27 (0) 11 392 3158
www.msd-animal-health.co.za

Manufacturer: Intervet International B.V.
35 Wim de Körverstraat, NL – 5831 AN Boxmeer, The Netherlands
DATE OF APPROVAL OF THIS PACKAGE INSERT: 30 January 2003